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Other factors in epidemiological studies that increase the risk of CDI include older age, gastrointestinal surgery, nasogastric tube feeding, reduced gastric acid, and concurrent disease, including inflammatory bowel disease (144,145,232,233,234,235,236). An impaired immune response has been implicated; a small series showed that patients with C.
Serious underlying illness and the presence of other concurrent diseases place the patient at increased risk of CDI, especially if the patient is receiving additional antibiotics for concurrent infections and has a longer hospital stay. As many risk factors for CDI are correlated, multivariate analysis provides independent risk estimates for variables that occur at the same time.
Most multivariate models find advanced age, antibiotic use, co-morbidities, and longer hospital stays are independently predictive of CDI (211,214,232).